UV-B Induced Changes in the Secondary Metabolites of Morus alba L. Leaves

Molecules

Xi-Da Gu¹  Ming-Yao Sun¹  Lin Zhang¹  Hong-Wei Fu¹  Lei Cui¹  Run-Ze Chen¹  Da-Wei Zhang¹ 

[1] ¹The Key Laboratory of Biomedical Engineering Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, Zhejiang, China ²College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China ³Department of Biological Sciences, University of Wisconsin—Milwaukee, Milwaukee, WI 53211, USA

关键词: UV radiation;    chalcomoracin;    moracin N;    Diels-Alder type adducts;    mulberry leaves;   

DOI  :  10.3390/molecules15052980

来源: mdpi

【 摘 要 】

Ultraviolet-B (UV-B) radiation is harmful to plants and human beings. Many secondary metabolites, like flavonoids, alkaloids, and lignin, are UV-B absorbing compounds, which can protect the genetic material of plants. Furthermore, they are active components of herbal drugs. UV-B radiation can activate the self-protective secondary metabolism system. The results of this paper provide a method to induce bioactive secondary metabolites from mulberry leaves (Morus alba L.) by UV-B irradiation in vitro. Five significantly different chromatographic peaks were found by HPLC fingerprint after induction, from which two active compounds were identified: One was chalcomoracin, a natural Diels-Alder type adduct with antibacterial activity; the other one was moracin N, which is a precursor of chalcomoracin. Their contents were 0.818 mg/g and 0.352 mg/g by dry weight, respectively.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.