Role of Lipids on Entry and Exit of Bluetongue Virus, a Complex Non-Enveloped Virus

Viruses

Bishnupriya Bhattacharya¹ 

[1] >London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK; E-Mail: [e-mail].

关键词: BTV;    non enveloped;    lipid rafts;    entry;    exit;   

DOI  :  10.3390/v2051218

来源: mdpi

【 摘 要 】

Non-enveloped viruses such as members of Picornaviridae and Reoviridae are assembled in the cytoplasm and are generally released by cell lysis. However, recent evidence suggests that some non-enveloped viruses exit from infected cells without lysis, indicating that these viruses may also utilize alternate means for egress. Moreover, it appears that complex, non-enveloped viruses such as bluetongue virus (BTV) and rotavirus interact with lipids during their entry process as well as with lipid rafts during the trafficking of newly synthesized progeny viruses. This review will discuss the role of lipids in the entry, maturation and release of non-enveloped viruses, focusing mainly on BTV.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland