Photochemical Transformations of Tetrazole Derivatives: Applications in Organic Synthesis

Molecules

Luís Miguel Teodoro Frija¹  Amin Ismael¹ 

[1] ¹CQFM - Centro de Química-Física Molecular, IN - Institute of Nanoscience and Nanotechnology, Departamento de Engenharia Química e Biológica, Instituto Superior Técnico, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal ²Departmento de Química e Farmácia, FCT, and CCMAR, Universidade do Algarve, Campus de Gambelas, 8005-039 Faro, Portugal

关键词: tetrazoles;    photochemistry;    UV-irradiation;    nitrogen heterocyles;    synthesis;   

DOI  :  10.3390/molecules15053757

来源: mdpi

【 摘 要 】

Tetrazoles remain a challenge to photochemists. Photolysis leads to cleavage of the tetrazolyl ring, may involve various photodegradation pathways and may produce a diversity of photoproducts, depending on the structure and conformational flexibility of the substituents and the possibility of tautomerism. If the photochemistry of tetrazoles is considered within the frame of synthetic applications the subject is even more challenging, since the ultimate goal is to achieve selectivity and high yield. In addition, the photoproducts must remain stable and allow isolation or trapping, in order to be used in other reactions. This review summarises the photochemical transformations of tetrazole derivatives that can be used as effective synthetic routes to other compounds.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.