HIV Nuclear Entry: Clearing the Fog

Viruses

Vaibhav B. Shah¹ 

[1] id="aff1">Department of Microbiology and Immunology, Vanderbilt University School of Medicine, A‑5301 Medical Center North, Nashville TN 37232-2363, USA; E-Mail: vaibhav.b.shah@vanderbilt.e

关键词: HIV-1;    capsid;    nuclear entry;    TNPO3;    nucleoporins;   

DOI  :  10.3390/v2051190

来源: mdpi

【 摘 要 】

HIV-1 and other lentiviruses have the unusual capability of infecting nondividing cells, but the mechanism by which they cross an intact nuclear membrane is mysterious. Recent work, including a new study (Lee, K.; Ambrose, Z.; Martin, T.D.; Oztop, I.; Mulky, A.; Julias, J.G.; Vandergraaff, N.; Baumann, J.G.; Wang, R.; Yuen, W. et al. Flexible use of nuclear import pathways by HIV-1. Cell Host Microbe 2010,7, 221-233) confirms that the viral capsid plays a key role in HIV-1 nuclear entry in both dividing and nondividing cells. The identification of mutations in the viral capsid that alter the virus’s dependence on host cell nucleoporins represents an important advance in this poorly understood stage of the virus life cycle.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland