Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid

Molecules

Xiao Jia Yin¹  Guan Hong Xu¹  Xu Sun¹  Yan Peng¹  Xing Ji¹  Ke Jiang¹ 

[1] ¹School of Pharmacy, Nanjing Medical University, Nanjing 210029, China ²Nanjing Children’s hospital, Nanjing Medical University, Nanjing 210008, China

关键词: bosutinib;    protein kinase inhibitors;    3-methoxy-4-hydroxybenzoic acid;   

DOI  :  10.3390/molecules15064261

来源: mdpi

【 摘 要 】

This paper reports a novel synthesis of bosutinib starting from 3-methoxy-4-hydroxybenzoic acid. The process starts with esterification of the starting material, followed by alkylation, nitration, reduction, cyclization, chlorination and two successive amination reactions. The intermediates and target molecule were characterized by ¹H-NMR, ¹³C-NMR, MS and the purities of all the compounds were determined by HPLC.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.