Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin

Cancers

Lara Gibellini¹  Marcello Pinti¹  Milena Nasi¹  Sara De Biasi¹  Erika Roat¹  Linda Bertoncelli¹ 

[1]Department of Biomedical Sciences, School of Medicine, University of Modena and Reggio Emilia, Via Campi 287, 41125 Modena, Italy

关键词: cancer;    reactive oxygen species;    redox homeostasis;    flavonoids;    quercetin;   

DOI  :  10.3390/cancers2021288

来源: mdpi

【 摘 要 】

A main feature of cancer cells, when compared to normal ones, is a persistent pro-oxidative state that leads to an intrinsic oxidative stress. Cancer cells have higher levels of reactive oxygen species (ROS) than normal cells, and ROS are, in turn, responsible for the maintenance of the cancer phenotype. Persistent ROS stress may induce adaptive stress responses, enabling cancer cells to survive with high levels of ROS and maintain cellular viability. However, excessive ROS levels render cancer cells highly susceptible to quercetin, one of the main dietary flavonoids. Quercetin depletes intracellular glutathione and increases intracellular ROS to a level that can cause cell death.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland.