Historical Perspectives in the Development of Antiviral Agents Against Poxviruses

Viruses

关键词: thiosemicarbazones;    interferon (inducers);    idoxuridine (IDU);    acyclic nucleoside phosphonates;    cidofovir;    CMX001 (HDP-CDV);    tecovirimat (ST-246);    Gleevec (imatinib);   

DOI  :  10.3390/v2061322

来源: mdpi

【 摘 要 】

The poxvirus vaccinia virus (VV) served as the model virus for which the first antivirals, the thiosemicarbazones, were identified. This dates back to 1950; and, although there is at present no single antiviral drug specifically licensed for the chemotherapy or -prophylaxis of poxvirus infections, numerous candidate compounds have been described over the past 50 years. These compounds include interferon and inducers thereof (i.e., polyacrylic acid), 5-substituted 2’-deoxyuridines (i.e., idoxuridine), IMP dehydrogenase inhibitors, S-adenosylhomocysteine hydrolase inhibitors, acyclic nucleoside phosphonates (such as cidofovir) and alkoxyalkyl prodrugs thereof (such as CMX001), viral egress inhibitors (such as tecovirimat), and cellular kinase inhibitors (such as imatinib).

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland