Pharmaceuticals | |
Unlocking the Door to Neuronal Woes in Alzheimer’s Disease: Aβ and Mitochondrial Permeability Transition Pore | |
Heng Du1  | |
[1]Department of Surgery, Physicians & Surgeons College of Columbia University, New York, NY 10032, USA | |
关键词: amyloid beta; mitochondrial permeability transition; cyclophilin D; therapy; | |
DOI : 10.3390/ph3061936 | |
来源: mdpi | |
![]() |
【 摘 要 】
Mitochondrial dysfunction occurs early in the progression of Alzheimer’s disease. Amyloid-β peptide has deleterious effects on mitochondrial function and contributes to energy failure, respiratory chain impairment, neuronal apoptosis, and generation of reactive oxygen species in Alzheimer’s disease. The mech
【 授权许可】
CC BY
© 2010 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202003190053369ZK.pdf | 250KB | ![]() |