Synthesis and in vitro Cytotoxicity of Novel Ursolic Acid Derivatives

Molecules

Yanqiu Meng¹  Yanling Song¹  Zhaokai Yan¹ 

[1] Department of Pharmaceutical Engineering, Shenyang University of Chemical Technology, Iiaoning 110042, China

关键词: ursolic acid derivatives;    structure modification;    anti-tumor activity;   

DOI  :  10.3390/molecules15064033

来源: mdpi

【 摘 要 】

In an effort to improve potential hepatoprotective and anti-tumor activities, eight novel ursolic acid (UA) derivatives were designed and synthesized with substitution at positions of C-3, C-11and C-28 of UA. Their structures were confirmed using IR, MS and ¹H-NMR and elemental analysis. Their in vitro cytotoxicity against various cancer cell lines (HeLa, SKOV3 and BGC-823) was evaluated by the standard MTT assay. Among them, compound 13 exhibited more potent cytotoxicity than ursolic acid.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.