Non-Steroidal Anti-Inflammatory Drugs: An Overview of Cardiovascular Risks

Pharmaceuticals

Inger L. Meek¹  Mart A.F.J. van de Laar¹ 

[1] Department of Rheumatology and Clinical Immunology, Medisch Spectrum Twente and University of Twente, Ariensplein 1, 7500 KA Enschede, The Netherlands;

关键词: NSAIDs;    aspirin;    cardiovascular events;   

DOI  :  10.3390/ph3072146

来源: mdpi

【 摘 要 】

While aspirin may offer protection, other non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) can cause serious cardiovascular side effects and complications. This has led to a general "black box" warning for cardiovascular adverse events for NSAIDs. This review explores the different mechanisms underlying the protective effects of aspirin, the NSAID associated renovascular effects causing hypertension, edema and heart failure, the cardiovascular effects causing myocardial infarction and stroke, and the possible deleterious interaction between NSAIDs and aspirin.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland.