Lipophilic Compound-Mediated Gene Expression and Implication for Intervention in Reactive Oxygen Species (ROS)-Related Diseases: Mini-review

Nutrients

Yukiko K. Nakamura¹ 

[1] Department of Nutrition, University of Nevada, Reno 1664 N, Nevada 89557-0208,USA;

关键词: antioxidant;    reactive oxygen species (ROS);    atherosclerosis;    conjugated linoleic acid (CLA);    vitamin E (or α-tocopherol);    peroxisome proliferator-activated receptor gamma (PPARγ);    nuclear factor kappa B (NF-κB);   

DOI  :  10.3390/nu2070725

来源: mdpi

【 摘 要 】

In addition to exhibiting antioxidant properties, conjugated linoleic acid (CLA) and vitamin E may modulate gene expression of endogenous antioxidant enzymes. Depending on cellular microenvironments, such modulation reflects either antioxidant or prooxidant outcomes. Although epidemiological/experimental studies have indicated that CLA and vitamin E have health promoting properties, recent findings from clinical trials have been inconclusive. Discrepancies between the results found from prospective studies and recent clinical trials might be attributed to concentration-dependent cellular microenvironment alterations. We give a perspective of possible molecular mechanisms of actions of these lipophilic compounds and their implications for interventions of reactive oxygen species (ROS)-related diseases.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland