Nutrients | |
Lipophilic Compound-Mediated Gene Expression and Implication for Intervention in Reactive Oxygen Species (ROS)-Related Diseases: Mini-review | |
Yukiko K. Nakamura1  | |
[1] Department of Nutrition, University of Nevada, Reno 1664 N, Nevada 89557-0208,USA; | |
关键词: antioxidant; reactive oxygen species (ROS); atherosclerosis; conjugated linoleic acid (CLA); vitamin E (or α-tocopherol); peroxisome proliferator-activated receptor gamma (PPARγ); nuclear factor kappa B (NF-κB); | |
DOI : 10.3390/nu2070725 | |
来源: mdpi | |
【 摘 要 】
In addition to exhibiting antioxidant properties, conjugated linoleic acid (CLA) and vitamin E may modulate gene expression of endogenous antioxidant enzymes. Depending on cellular microenvironments, such modulation reflects either antioxidant or prooxidant outcomes. Although epidemiological/experimental studies have indicated that CLA and vitamin E have health promoting properties, recent findings from clinical trials have been inconclusive. Discrepancies between the results found from prospective studies and recent clinical trials might be attributed to concentration-dependent cellular microenvironment alterations. We give a perspective of possible molecular mechanisms of actions of these lipophilic compounds and their implications for interventions of reactive oxygen species (ROS)-related diseases.
【 授权许可】
CC BY
© 2010 by the authors; licensee MDPI, Basel, Switzerland
【 预 览 】
Files | Size | Format | View |
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RO202003190053161ZK.pdf | 95KB | download |