Perinatal Bisphenol A Exposure in C57B6/129svj Male Mice: Potential Altered Cytokine/Chemokine Production in Adulthood

International Journal of Environmental Research and Public Health

Steven D. Holladay¹  Shuo Xiao⁴  Honglu Diao⁴  Jamie Barber²  Tomas Nagy³  Xiaoqin Ye⁴ 

[1] Department of Anatomy and Radiology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, GA 30602, USA;Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, GA 30602, USA;Pathology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, GA 30602, USA;Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, GA 30602, USA

关键词: bisphenol;    developmental;    cytokines;    immune;   

DOI  :  10.3390/ijerph7072845

来源: mdpi

【 摘 要 】

Pregnant mice (n = 3) were exposed to BPA by intraperitoneal injection, from gestation day 9.5 until end of lactation. Male offspring were evaluated for cytokine production at 20 wk-of-age. One pregnant control mouse produced no males, precluding statistical analysis. However, recurring shifts in cytokines were suggested in the adult BPA offspring. Serum showed a numeric increase in 16 of 21 basal cytokine levels. ConA-stimulated splenocytes showed a numeric increase in 17 of 21 cytokines, and LPS-stimulated splenocytes an increase in 18 of 21 cytokines. The cytokine profile was one of T_H1 up-regulation more than T_H2, and with skewing toward T_H17 responses.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.