Optical Sensors Based on Whispering Gallery Modes in Fluorescent Microbeads: Response to Specific Interactions

Sensors

Michael Himmelhaus¹  Sivashankar Krishnamoorthy¹ 

[1] Fujirebio, Inc., 51 Komiya-cho, Hachioji-shi 192-0031, Tokyo, Japan

关键词: whispering gallery modes;    cavity modes;    optical sensing;    refractive index sensing;    biosensing;    label-free detection;   

DOI  :  10.3390/s100606257

来源: mdpi

【 摘 要 】

Whispering gallery modes (WGMs) in surface-fixated fluorescent polystyrene microbeads are studied in view of their capability of sensing the formation of biochemical adsorption layers on their outer surface with the well-established biotin-streptavidin specific binding as the model system. Three different methods for analysis of the observed shifts in the WGM wavelength positions are applied and used to quantify the adsorbed mass densities, which are then compared with the results of a comparative surface plasmon resonance (SPR) study.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland.