Short-Term Effect of Prebiotics Administration on Stool Characteristics and Serum Cytokines Dynamics in Very Young Children with Acute Diarrhea

Nutrients

Nachum Vaisman²  Josef Press⁴  Eugene Leibovitz¹  G࿎nther Boehm³ 

[1]Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer-Sheva, 84111, Israel

[2]

[3]Unit of Clinical Nutrition, Tel Aviv Sourasky Medical Center, Sackler Faulty of Medicine, Tel Aviv University, Tel Aviv, 64239, IsraelDanone Research Friedrichsdorf, Germany and Sophia Children’s Hospital, Erasmus University, Rotterdam, 3015GJ, The Netherlands

[4]Pediatric Emergency Room, Soroka University Medical Center, Beer-Sheva, 84101, Israel

关键词: diarrhea;    infants;    prebiotics;    galacto-oligosaccharides;    fructo-oligosaccharides;    galacturonic oligosaccharides;    cytokines;   

DOI  :  10.3390/nu2070683

来源: mdpi

【 摘 要 】

We investigated the effect of a mixture of long-chain fructo-oligosaccharides, galacto-oligosaccharides and acidic oligosaccharides on the number and consistency of stools and on immune system biomarkers in 104 supplemented and non-supplemented subjects (aged 9-24 months) with acute diarrhea. Interleukin-1 (IL-1), IL-1RA, IL-6, IL-8, IL-10, TNF-α and sIL-2R cytokine levels were determined. The significant decrease in number of stools and increase in stool consistency in the supplemented group was of little clinical relevance. The only significant change in pro- and anti-inflammatory cytokines was decreased TNF-α levels in the supplemented group. Prebiotic supplementation during acute diarrhea episodes did not influence the clinical course.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland