Uncoupling of T Cell Receptor Zeta Chain Function during the Induction of Anergy by the Superantigen, Staphylococcal Enterotoxin A

Toxins

William D. Cornwell¹ 

[1] FELS Institute, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140, USA;

关键词: superantigen;    Staphylococcus aureus;    SEA;    anergy;    zeta chain;    enterotoxin;   

DOI  :  10.3390/toxins2071704

来源: mdpi

【 摘 要 】

Staphylococcus aureus enterotoxins have immunomodulatory properties. In this study, we show that Staphylococcal enterotoxin A (SEA) induces a strong proliferative response in a murine T cell clone independent of MHC class II bearing cells. SEA stimulation also induces a state of hypo-responsiveness (anergy). We characterized the components of the T cell receptor (TCR) during induction of anergy by SEA. Most interestingly, TCR zeta chain phosphorylation was absent under SEA anergizing conditions, which suggests an uncoupling of zeta chain function. We characterize here a model system for studying anergy in the absence of confounding costimulatory signals.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland