Solid-Phase Synthesis of New Trp(Nps)-Containing Dipeptide Derivatives as TRPV1 Channel Blockers

Molecules

Mª Jesús Pérez De Vega¹  Mª Teresa García-López¹  Laura Zaccaro¹  Miriam Royo¹  Fernando Albericio¹  Asia Fernández-Carvajal¹  Antonio Ferrer-Montiel¹ 

[1] ¹Instituto de Química Médica, CSIC, Juan de la Cierva, 3, 28006 Madrid, Spain

关键词: solid-phase;    Trp(Nps) dipeptides;    TRPV1 channel blockers;   

DOI  :  10.3390/molecules15074924

来源: mdpi

【 摘 要 】

Trp(Nps)-Lys-NH₂ derivatives, bearing alkyl or guanidine groups either at the N–terminus or on the Lys side-chain or at both positions were conveniently prepared on solid-phase and evaluated as TRPV1 channel antagonists.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.