Antiplatelet Aggregation and Platelet Activating Factor (PAF) Receptor Antagonistic Activities of the Essential Oils of Five Goniothalamus Species

Molecules

Bushra Abdulkarim Moharam¹  Ibrahim Jantan¹  Fasihuddin bin Ahmad¹ 

[1] ¹Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia ²Faculty of Resources Science and Technology, Universiti Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia

关键词: Goniothalamus species;    essential oils;    GC-MS;    antiplatelet aggregation;    platelet activating factor (PAF) antagonists;   

DOI  :  10.3390/molecules15085124

来源: mdpi

【 摘 要 】

Nine essential oils, hydrodistilled from different parts of five Goniothalamus species (G. velutinus Airy-Shaw, G. woodii Merr., G. clemensii Ban, G. tapis Miq. and G. tapisoides Mat Salleh) were evaluated for their ability to inhibit platelet aggregation in human whole blood using an electrical impedance method and their inhibitory effects on platelet activating factor (PAF) receptor binding with rabbit platelets using ³H-PAF as a ligand. The chemical composition of the oils was analyzed by gas chromatography (GC) and gas chromatography–mass spectrometry (GC–MS). The bark oil of G. velutinus was the most effective sample as it inhibited both arachidonic acid (AA) and ADP-induced platelet aggregation with IC₅₀ values of 93.6 and 87.7 µg/mL, respectively. Among the studied oils, the bark oils of G. clemensii, G. woodii, G. velutinus and the root oil of G. tapis showed significant inhibitory effects on PAF receptor binding, with IC₅₀ values ranging from 3.5 to 10.5 µg/mL. The strong PAF antagonistic activity of the active oils is related to their high contents of sesquiterpenes and sesquiterpenoids, and the individual components in the oils could possibly produce a synergistic effect in the overall antiplatelet activity of the oils.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.