Synthesis and Antimicrobial Activity of Some New Quinoxaline Derivatives

Pharmaceuticals

Dharmchand Prasad Singh¹  Sanjay Kumar Deivedi¹  Syed Riaz Hashim¹ 

[1] Department of Pharmaceutical Chemistry, College of Pharmacy, Institute of Foreign Trade and Management, Moradabad - 244001, India; E-Mails:

关键词: quinoxalines;    benzamine;    benzaldehyde;    antimicrobial activity;   

DOI  :  10.3390/ph3082416

来源: mdpi

【 摘 要 】

2-Chloro-3-methylquinoxaline was selected as a nucleus around which various molecular transformations were performed to obtain new compounds expected to possess optimized antimicrobial activity. As very little work regarding attachment of ether linkages replacing chlorine at C-2 has been reported, it was thought worthwhile to synthesize various quinoxaline derivatives by replacing the C₂ chlorine with an ether linkage attached to a benzene ring possessing an aldehyde or a free amino group which can be further reacted with aromatic amines and aromatic aldehydes, respectively, to yield new Schiff bases containing quinoxaline moieties. Thus the compounds 4-(2-methylquinoxalinyloxy) benzaldehyde (4), 2-[4-(substituted-benziminomethyl)-phenoxy]-3-methyl quinoxalines 5a–e, 4-(2-methyl-quinoxaline-3-yloxy)benzamine (6) and 4-(2-methylquinoxalin-3-yloxy)-N-substituted benzylidine benzamines 7a–e were synthesized and tested for their antimicrobial activity. The structures of the compounds were confirmed on the basis of their elemental and spectral data.

【 授权许可】

CC BY   
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