Click Reactions and Boronic Acids: Applications, Issues, and Potential Solutions

Molecules

Chaofeng Dai¹  Yunfeng Cheng¹  Jianmei Cui¹ 

[1]Department of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, Georgia, 30303, USA

关键词: Click chemistry;    CuAAC;    Boronic acids;   

DOI  :  10.3390/molecules15085768

来源: mdpi

【 摘 要 】

Boronic acids have been widely used in a wide range of organic reactions, in the preparation of sensors for carbohydrates, and as potential pharmaceutical agents. With the growing importance of click reactions, inevitably they are also applied to the synthesis of compounds containing the boronic acid moiety. However, such applications have unique problems. Chief among them is the issue of copper-mediated boronic acid degradation in copper-assisted [2,3]-cycloadditions involving an alkyne and an azido compound as the starting materials. This review summarizes recent developments, analyzes potential issues, and discusses known as well as possible solutions.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.