Asymmetric Synthesis of α-Aminophosphonates Using the Inexpensive Chiral Catalyst 1,1’-Binaphthol Phosphate

Molecules

Weiming Xu¹  Sha Zhang¹  Song Yang¹  Lin-Hong Jin¹  Pinaki S. Bhadury¹  De-Yu Hu¹ 

[1] State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China

关键词: α-aminophosphonate derivatives;    aldimines;    cinnamaldehyde;    chiral organo- catalyst;    asymmetric addition;   

DOI  :  10.3390/molecules15085782

来源: mdpi

【 摘 要 】

Asymmetric addition under mild conditions of dialkyl phosphites on aldimines derived from cinnamaldehyde catalyzed by the inexpensive chiral organocatalyst (R)-3,3’-[4-fluorophenyl]₂-1,1’-binaphthol phosphate has been found effective to give new α-amino-phosphonates 9 in moderate yields (30–65%) and enantiomeric excess (8.4%–61.9%).

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.