Development of Treatment Concepts for the Use of Botulinum Toxin A in Children with Cerebral Palsy

Toxins

Richard Placzek²  Dagmar Siebold¹ 

[1] Centre for physiotherapy and neurorehabilitation, Berlin, Germany;Department of Paediatric Orthopaedics, Centre for Musculoskeletal Surgery, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany;

关键词: botulinum toxin A;    cerebral palsy;    CP;    multi-level treatment;    key-muscle concept;   

DOI  :  10.3390/toxins2092258

来源: mdpi

【 摘 要 】

The treatment of children with cerebral palsy with Botulinum toxin A injections is well established, safe and effective. However, a standardized injection strategy is still missing and the used dosage has escalated over the years. In the recent past, the recommended dosages in Europe were, however, reduced due to a better understanding of the relationship between dosage, severe side effects and the kind of anesthesia used. To combine safety and efficacy, the trend tends to a lower dosage, but combined with a more specific selection of injected muscles. The treatment of these key-muscles takes into account the best support for motor development to attain each individual motor milestone.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland