An Efficient Procedure Based on a MW-Assisted Horner–Wadsworth-Emmons Reaction for the Synthesis of (Z)-3,3-Trisubstituted-a,b-unsaturated Esters

Molecules

Daniela Rossi¹  Anna Carnevale Baraglia¹  Massimo Serra¹  Ornella Azzolina¹ 

[1] Dipartimento di Chimica Farmaceutica, viale Taramelli 12, Pavia 27100, Italy

关键词: (Z)-3;    3-trisubstituted α;    β-unsaturated methyl esters;    aryl-alkyl ketones;    Horner–Wadsworth-Emmons reaction;    microwave-assisted reactions;   

DOI  :  10.3390/molecules15095928

来源: mdpi

【 摘 要 】

A microwave-assisted HWE olefination process of readily accessible aryl-alkyl ketones has been developed to provide a rapid access to (Z)-3,3-trisubstituted-α,β-unsaturated methyl esters, key building blocks for the synthesis of biologically active compounds.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.