2-(Penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)thiophene, a Novel NQO1 Inducing Agent from Echinops grijsii Hance

Molecules

Jing Shi¹  Xiaoyu Zhang¹ 

[1] ¹Department of Pharmacy, Zhejiang Medical College, No.481 Binwen Rd., Hangzhou 310053, China

关键词: Echinops grijsii hance;    PDDYT;    NQO1;    Nrf2;    glutathione;    Akt;   

DOI  :  10.3390/molecules15085273

来源: mdpi

【 摘 要 】

A natural alkynol group-substituted thiophene, 2-(penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)-thiophene (PDDYT), was isolated from the roots of Echinops grijsii Hance. It possessed potent NAD(P)H: quinone oxidoreductase1 (NQO1) inducing activity and could activate Keap1-Nrf2 pathway effectively in murine hepatoma Hepa 1c1c7 cells. Further investigations indicated that the activation of Keap1-Nrf2 pathway by PDDYT might be attributed to the activation of Akt and depleting the cellular glutathione (GSH).

【 授权许可】

CC BY   
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