Synthesis, Identification and Anti-Cancer Activity of 1-(4-Methylpent-2-enyl)-2-(4-phenylbut-2-enyl)disulfane

Molecules

Chunxiao Ji¹  Fenglian Ren¹ 

[1] ¹College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China ²Research Institute for Molecular Pharmacology and Therapeutics, Central South University, Changsha, Hunan 410083, China

关键词: 1-(4-methylpent-2-enyl)-2-(4-phenylbut-2-enyl)disulfane;    synthesis;    anti-cancer activity;    XIAP;   

DOI  :  10.3390/molecules15085671

来源: mdpi

【 摘 要 】

In this study, we synthesized 1-(4-methylpent-2-enyl)-2-(4-phenylbut-2- enyl)disulfane using sodium sulfide, 1-bromine-4-methyl-2-amylene and 1-(4-bromine-2- butylene)benzene as raw materials. The yield rate of target product was 84%. The structure of the target product was confirmed by GC-MS, ¹H-NMR and elemental analysis. The results of anti-cancer activity experiments showed that 1-(4-methylpent-2-enyl)-2-(4- phenylbut-2-enyl)disul-fane could significantly inhibit the proliferation, induce the apoptosis of CNE2 cells in a dose dependent manner, and could significantly enhance the activity of XIAP.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.