ADAM-15 Disintegrin-Like Domain Structure and Function

Toxins

Dong Lu¹  Mike Scully¹  Vijay Kakkar¹ 

[1] Thrombosis Research Institute, Manresa Road, London, SW3 6LR, UK;

关键词: ADAM protein;    Snake venom toxin;    disintegrin;    integrin;    RGD-motif;   

DOI  :  10.3390/toxins2102411

来源: mdpi

【 摘 要 】

The ADAM (a disintegrin-like and metalloproteinase) proteins are a family of transmembrane cell-surface proteins with important functions in adhesion and proteolytic processing in all animals. Human ADAM-15 is the only member of the ADAM family with the integrin binding motif Arg-Gly-Asp (RGD) in its disintegrin-like domain. This motif is also found in most snake venom disintegrins and other disintegrin-like proteins. This unique RGD motif within ADAM-15 serves as an integrin ligand binding site, through which it plays a pivotal role in interacting with integrin receptors, a large family of heterodimeric transmembrane glycoproteins. This manuscript will present a review of the RGD-containing disintegrin-like domain structures and the structural features responsible for their activity as antagonists of integrin function in relation to the canonical RGD template.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland