Structural and Pharmacological Effects of Ring-Closing Metathesis in Peptides

Molecules

Øyvind Jacobsen¹  Jo Klaveness¹ 

[1] School of Pharmacy, University of Oslo, Sem Sælands vei 3, P. O. Box 1068 Blindern, 0316 Oslo, Norway

关键词: ring-closing metathesis;    peptides;    structure;    pharmacological properties;   

DOI  :  10.3390/molecules15096638

来源: mdpi

【 摘 要 】

Applications of ring-closing alkene metathesis (RCM) in acyclic α- and β-peptides and closely related systems are reviewed, with a special emphasis on the structural and pharmacological effects of cyclization by RCM.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.