In Vivo Biocompatibility Study of Electrospun Chitosan Microfiber for Tissue Engineering

International Journal of Molecular Sciences

Yun Mi Kang¹  Bit Na Lee¹  Jae Hoon Ko²  Gyeong Hae Kim¹  Kkot Nim Kang¹  Da Yeon Kim¹  Jae Ho Kim¹  Young Hwan Park²  Heung Jae Chun³  Chun Ho Kim⁴ 

[1] Department of Molecular Science and Technology, Ajou University, Suwon, 443-749, Korea; E-Mails:;Digital Dyeing & Finishing Tech, Korea Institute of Industrial Technology, Ansan, 426-791, Korea; E-Mails:;Department of Biomedical Sciences, College of Medicine, Catholic University, Seoul, 137-701, Korea; E-Mail:;Laboratory of Tissue Engineering, Korea Institute of Radiological and Medical Sciences, Seoul, 139-706, Korea; E-Mail:

关键词: electrospun;    chitosan;    microfibers;    scaffold;    stem cell;   

DOI  :  10.3390/ijms11104140

来源: mdpi

【 摘 要 】

In this work, we examined the biocompatibility of electrospun chitosan microfibers as a scaffold. The chitosan microfibers showed a three-dimensional pore structure by SEM. The chitosan microfibers supported attachment and viability of rat muscle-derived stem cells (rMDSCs). Subcutaneous implantation of the chitosan microfibers demonstrated that implantation of rMDSCs containing chitosan microfibers induced lower host tissue responses with decreased macrophage accumulation than did the chitosan microfibers alone, probably due to the immunosuppression of the transplanted rMDSCs. Our results collectively show that chitosan microfibers could serve as a biocompatible in vivo scaffold for rMDSCs in rats.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.