Targeted Thiazole Orange Derivative with Folate: Synthesis, Fluorescence and in Vivo Fluorescence Imaging

Molecules

Xuening Fei¹  Yingchun Gu¹  Yiqi Wang¹  Qingyang Meng¹ 

[1] ¹School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China ²Department of Material Science and Engineering, Tianjin Institute of Urban Construction, Tianjin, 300384, China

关键词: thiazole orange;    folate;    synthesis;    targeted label in vivo;    fluorescence imaging;   

DOI  :  10.3390/molecules15106983

来源: mdpi

【 摘 要 】

A Thiazole Orange conjugated with folate derivative was synthesized in two steps. Firstly, folate was coupled with 1-(3-aminopropyl)-4-methylquinolinium bromide to afford folate-methylquinolinium bromide, which then reacted with benzothiazolium to obtain the title folate-conjugated compound. The compound was evaluated by ¹H-NMR MS, TG/DTA and fluorescence spectroscopic methods. The title compound could selectively target folate receptor expressing tumors according to the in vivo fluorescence imaging preliminarily performed on nude mice with breast tumors.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.