The Fungicidal Terpenoids and Essential Oil from Litsea cubeba in Tibet

Molecules

Yu Yang¹  Jiazheng Jiang¹  Luobu Qimei¹  Xiaojing Yan¹  Junxia Zhao¹  Huizhu Yuan¹  Zhaohai Qin¹ 

[1] ¹Department of Applied Chemistry, China Agricultural University, Beijing 100193, China ²Department of Chemistry, College of Sciences, Tibet University, Lhasa 850000, China ³Institute of Plant Protection, China Academy of Agricultural Sciences, Beijing 100193, China

关键词: Litsea cubeba;    Lauraceae;    (6R)-3;    7-dimethyl-7-hydroxy-2-octen-6-olide;    litseacubebic acid;    essential oil;    fungicidal activity;   

DOI  :  10.3390/molecules15107075

来源: mdpi

【 摘 要 】

A new C₉ monoterpenoid acid (litseacubebic acid, 1) and a known monoterpene lactone (6R)-3,7-dimethyl-7-hydroxy-2-octen-6-olide (2), along with three known compounds – vanillic acid (3), trans-3,4,5-trimethoxylcinnamyl alcohol (4), and oxonantenine (5) – were isolated with bioassay-guided purification from the fruit extract of Litsea cubeba collected in Tibet. The structure of 1 was elucidated by MS, ¹H-NMR, ¹³C-NMR, COSY, HSQC, HMBC, NOE spectral data as 2,6-dimethyl-6-hydroxy-2E,4E-hepta-2,4-diene acid. Additionally 33 compounds were identified from the essential oil of L. cubeba. The preliminary bioassay results showed that 1 and 2 have good fungicidal activities against Sclerotinia sclerotiorum, Thanatephorus cucumeris, Pseudocer-cospora musae and Colletotrichum gloeosporioides at the concentration of 588 and 272 μM, and the essential oil has good fungicidal activities against T. cucumeris and S. sclerotiorum, with IC₅₀ values of 115.58 and 151.25 μg/mL, repectively.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.