Antimutagenicity and Antiproliferative Studies of Lipidic Extracts from White Shrimp (Litopenaeus vannamei)

Marine Drugs

Griselda Wilson-Sanchez³  Carolina Moreno-Félix³  Carlos Velazquez¹  Maribel Plascencia-Jatomea³  Anita Acosta¹  Lorena Machi-Lara²  Mar໚-Lourdes Aldana-Madrid³  Josafat-Marina Ezquerra-Brauer³  Ramón Robles-Zepeda¹ 

[1] Departamento de Ciencias Químico Biológicas, Universidad de Sonora, Apartado Postal 1658, Hermosillo, Sonora, Mexico; E-Mails:;Departamento de Investigación en Polímeros y Materiales, Universidad de Sonora, Apartado Postal 1658, Hermosillo, Sonora, Mexico; E-Mail:;Departamento de Investigación y Posgrado en Alimentos, Universidad de Sonora, Apartado Postal 1658, Hermosillo, Sonora, Mexico; E-Mails:

关键词: antimutagenicity;    antiproliferation;    cultured shrimp;   

DOI  :  10.3390/md8112795

来源: mdpi

【 摘 要 】

An organic extract from fresh shrimp (Litopenaeus vannamei) was studied for antimutagenic and antiproliferative properties using Salmonella typhimurium tester strains TA98 and TA100 with metabolic activation (S9) and a cancer cell line (B-cell lymphoma), respectively. Shrimp extract was sequentially fractionated by thin layer chromatography (TLC) and each fraction was tested for antimutagenic and antiproliferative activities. Crude organic extracts obtained from shrimp reduced the number of revertants caused by aflatoxina B₁, showing a dose-response type of relationship. Sequential TLC fractionation of the active extracts produced several antimutagenic and/or antiproliferative fractions. These results suggested that the lipid fraction of the tested species contained compounds with chemoprotective properties that reduce the mutagenicity of AFB₁ and proliferation of a cancer cell line.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland