Recent Advance in Heterocyclic Organozinc and Organomanganese Compounds; Direct Synthetic Routes and Application in Organic Synthesis

Molecules

Seung-Hoi Kim¹ 

[1] ¹Department of Chemistry, Dankook University; 29 Anseo Cheonan Chungnam, 330-714, Korea ²Rieke Metals, Inc.; 1001 Kingbird Rd. Lincoln, NE 68512, USA

关键词: highly active metals;    organozinc;    organomanganese;    heterocyclic compounds;   

DOI  :  10.3390/molecules15118006

来源: mdpi

【 摘 要 】

A practical synthetic route for the preparation of 2-pyridyl and 3-pyridyl derivatives has been accomplished by utilizing a simple coupling reaction of stable 2-pyridylzinc bromides and 3-pyridylzinc bromides. The organozincs used in this study were easily prepared via the direct insertion of active zinc into the corresponding bromopyridines. The subsequent coupling reactions with a variety of different electrophiles have afforded the corresponding coupling products. Using highly active manganese, a variety of Grignard-type organomanganese reagents have been obtained. The subsequent coupling reactions of the resulting organomanganese reagents with several electrophiles have also been accomplished under mild conditions.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.