MimoDB: a New Repository for Mimotope Data Derived from Phage Display Technology

Molecules

Beibei Ru¹  Jian Huang¹  Ping Dai¹  Shiyong Li¹  Zhongkui Xia¹  Hui Ding¹  Hao Lin¹  Feng-Biao Guo¹ 

[1] Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China

关键词: mimotope;    phage display;    biopanning;    combinatorial libraries;    target-unrelated peptides;   

DOI  :  10.3390/molecules15118279

来源: mdpi

【 摘 要 】

Peptides selected from phage-displayed random peptide libraries are valuable in two aspects. On one hand, these peptides are candidates for new diagnostics, therapeutics and vaccines. On the other hand, they can be used to predict the networks or sites of protein-protein interactions. MimoDB, a new repository for these peptides, was developed, in which 10,716 peptides collected from 571 publications were grouped into 1,229 sets. Besides peptide sequences, other important information, such as the target, template, library and complex structure, was also included. MimoDB can be browsed and searched through a user-friendly web interface. For computational biologists, MimoDB can be used to derive customized data sets and benchmarks, which are useful for new algorithm development and tool evaluation. For experimental biologists, their results can be searched against the MimoDB database to exclude possible target-unrelated peptides. The MimoDB database is freely accessible at http://immunet.cn/mimodb/.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.