Pancreatic Lipase Inhibition by C-Glycosidic Flavones Isolated from Eremochloa ophiuroides

Molecules

Eun Mi Lee¹  Seung Sik Lee¹  Byung Yeoup Chung¹  Jae-Young Cho¹  In Chul Lee¹  So Ra Ahn¹  Soo Jeung Jang¹ 

[1] ¹Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Institute (KAERI), Jeongeup 580-185, Korea

关键词: Eremochloa ophiuroides;    C-glycosidic flavones;    obesity;    pancreatic lipase;   

DOI  :  10.3390/molecules15118251

来源: mdpi

【 摘 要 】

Activity-guided fractionation of a methanolic extract of the leaves of Eremochloa ophiuroides (centipede grass) using a pancreatic lipase inhibitory assay led to the isolation and identification of a new C-glycosidic flavone, luteolin 6-C-b-D-boivinopyranoside (1), as well as eight known compounds. The structures of these compounds were established on the basis of interpretation of their spectroscopic data. Among these isolates, the C-glycosidic flavones 1–5 showed potent inhibitory effects on pancreatic lipase, with IC₅₀ values ranging from 18.5 ± 2.6 to 50.5 ± 3.9 mM.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.