Possible Role of Autophagy in the Treatment of Pancreatic Cancer with Histone Deacetylase Inhibitors

Cancers

关键词: pancreatic cancer;    autophagy;    apoptosis;    epigenetics;    histone deacetylase;    ER stress;   

DOI  :  10.3390/cancers2042026

来源: mdpi

【 摘 要 】

Pancreatic cancer is a lethal disease and notoriously difficult to treat. Only a small proportion is curative by surgical resection, whilst standard chemotherapy for patients with advanced disease has only a modest effect with substantial toxicity. Clearly there is a need for the continual development of novel therapeutic agents to improve the current situation. Currently, there is a bulk of data indicating the important function of autophagy in cancer. While genetic evidence indicates that autophagy functions as a tumor suppressor, it is also apparent that autophagy can promote the survival of established tumors under stress conditions and in response to chemotherapy. This review provides a spectrum of potential pharmacological agents and autophagic approaches to enhance cell killing in pancreatic cancer.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland.