Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR

Molecules

Xiangchen Huang¹  Min Dong¹  Jian Liu¹  Kehui Zhang¹  Zhenjun Yang¹  Liangren Zhang¹ 

[1] State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China

关键词: cADPR analogue;    acyclic cADPR analogue;    trifluoromethylation;    synthesis;   

DOI  :  10.3390/molecules15128689

来源: mdpi

【 摘 要 】

A novel trifluoromethylated analogue of cADPR, 8-CF₃-cIDPDE (5) was designed and synthesized via construction of N¹,N⁹-disubstituted hypoxanthine, trifluoromethylation and intramolecular condensation. A series of acyclic analogues of cADPR were also designed and synthesized. These compounds could be useful molecules for studying the structure-activity relationship of cADPR analogues and exploring the cADPR/RyR Ca²⁺ signalling system.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.