Molecules | |
Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR | |
Xiangchen Huang1  Min Dong1  Jian Liu1  Kehui Zhang1  Zhenjun Yang1  Liangren Zhang1  | |
[1] State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China | |
关键词: cADPR analogue; acyclic cADPR analogue; trifluoromethylation; synthesis; | |
DOI : 10.3390/molecules15128689 | |
来源: mdpi | |
【 摘 要 】
A novel trifluoromethylated analogue of cADPR, 8-CF3-cIDPDE (5) was designed and synthesized via construction of N1,N9-disubstituted hypoxanthine, trifluoromethylation and intramolecular condensation. A series of acyclic analogues of cADPR were also designed and synthesized. These compounds could be useful molecules for studying the structure-activity relationship of cADPR analogues and exploring the cADPR/RyR Ca2+ signalling system.
【 授权许可】
CC BY
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
【 预 览 】
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