Estimating Plasma Glucose from Interstitial Glucose: The Issue of Calibration Algorithms in Commercial Continuous Glucose Monitoring Devices

Sensors

Paolo Rossetti²  Jorge Bondia²  Josep Vehí¹ 

[1]Institut d’Informatica i Aplicacions, Universitat de Girona/Campus Montilivi, Girona, Spain

[2] E-Mail:

[3]Instituto Universitario de Automática e Informática Industrial, Universidad Politécnica de Valencia, Camino de Vera, s/n, 46022 Valencia, Spain

[4] E-Mail:

关键词: continuous glucose monitoring;    calibration algorithms;   

DOI  :  10.3390/s101210936

来源: mdpi

【 摘 要 】

Evaluation of metabolic control of diabetic people has been classically performed measuring glucose concentrations in blood samples. Due to the potential improvement it offers in diabetes care, continuous glucose monitoring (CGM) in the subcutaneous tissue is gaining popularity among both patients and physicians. However, devices for CGM measure glucose concentration in compartments other than blood, usually the interstitial space. This means that CGM need calibration against blood glucose values, and the accuracy of the estimation of blood glucose will also depend on the calibration algorithm. The complexity of the relationship between glucose dynamics in blood and the interstitial space, contrasts with the simplistic approach of calibration algorithms currently implemented in commercial CGM devices, translating in suboptimal accuracy. The present review will analyze the issue of calibration algorithms for CGM, focusing exclusively on the commercially available glucose sensors.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland.