Genes | |
Synaptonemal Complex Length Variation in Wild-Type Male Mice | |
Neil M. Vranis1  Godfried W. van der Heijden2  Safia Malki2  | |
[1] Johns Hopkins University, Baltimore, MD 21218, USA; E-Mail:;Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218, USA; E-Mails: | |
关键词: synaptonemal complex; meiosis; mouse; genetic background; synapsis; REC8; | |
DOI : 10.3390/genes1030505 | |
来源: mdpi | |
【 摘 要 】
Meiosis yields haploid gametes following two successive divisions of a germ cell in the absence of intervening DNA replication. Balanced segregation of homologous chromosomes in Meiosis I is aided by a proteinaceous structure, the synaptonemal complex (SC). The objective of this study was to determine total average autosomal SC lengths in spermatocytes in three commonly used mouse strains (129S4/SvJae, C57BL/6J, and BALB/c). Our experiments revealed that the total autosomal SC length in BALB/c spermatocytes is 9% shorter than in the two other strains. Shorter SCs are also observed in spermatocytes of (BALB/c × 129S4/SvJae) and (C57BL/6J × BALB/c) F1 hybrids suggesting a genetic basis of SC length regulation. Along these lines, we studied expression of a selected group of genes implicated in meiotic chromosome architecture. We found that BALB/c testes express up to 6-fold less of
【 授权许可】
CC BY
© 2010 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190051570ZK.pdf | 424KB | download |