Biological Activity of Volatiles from Marine and Terrestrial Bacteria

Marine Drugs

Stefan Schulz³  Jeroen S. Dickschat³  Brigitte Kunze¹  Irene Wagner-Dobler¹  Randi Diestel² 

[1] Research Group Microbial Communication, Helmholtz Center for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany; E-Mails:;Department of Chemical Biology, Helmholtz Center for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany; E-Mails:;Institute of Organic Chemistry, University of Braunschweig—Institute of Technology, Hagenring 30, 38106 Braunschweig, Germany; E-Mail:

关键词: lactones;    sulfur compounds;    pyrazines;    bacterial communication;    quorum-sensing;    ketones;    aromatic compounds;    agar diffusion assay;    terpenes;   

DOI  :  10.3390/md8122976

来源: mdpi

【 摘 要 】

The antiproliferative activity of 52 volatile compounds released from bacteria was investigated in agar diffusion assays against medically important microorganisms and mouse fibroblasts. Furthermore, the activity of these compounds to interfere with the quorum-sensing-systems was tested with two different reporter strains. While some of the compounds specific to certain bacteria showed some activity in the antiproliferative assay, the compounds common to many bacteria were mostly inactive. In contrast, some of these compounds were active in the quorum-sensing-tests. γ-Lactones showed a broad reactivity, while pyrazines seem to have only low intrinsic activity. A general discussion on the ecological importance of these findings is given.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland