Synthesis of Substituted 1,4-Diazepines and 1,5-Benzodiazepines Using an Efficient Heteropolyacid-Catalyzed Procedure

Molecules

Rachedine Kaoua¹  Norah Bennamane¹  Saliha Bakhta¹  Sihame Benadji¹  Cherifa Rabia¹ 

[1] ¹Laboratory of Applied Organic Chemistry, Houari Boumediene University of Sciences and Technology, BP 31, El-Alia, Bab-Ezzouar, 16111, Algiers, Algeria

关键词: 1;    4-diazepine;    1;    5-benzodiazepine;    dehydroacetic acid;    1;    3-aminomethyl propane;    orthophenylene diamine;    heteropolyacids;   

DOI  :  10.3390/molecules16010092

来源: mdpi

【 摘 要 】

An efficient and improved procedure for the synthesis of 1,4-diazepine and 1,5-benzodiazepine derivatives via the reaction of ketimine intermediates with aldehydes in the presence of Keggin-type heteropolyacids (HPAs) was developed. High yields and short reaction times were obtained for both electron-releasing and electron-withdrawing substituted 1,4-diazepine  and 1,5-benzodiazepines derivatives.

【 授权许可】

CC BY   
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