Anticoagulation in the Elderly

Pharmaceuticals

Helia Robert-Ebadi¹ 

关键词: anticoagulation;    elderly patient;    vitamin K antagonist;    hemorrhagic risk;    factor-Xa inhibitor;    thrombin inhibitors;   

DOI  :  10.3390/ph3123543

来源: mdpi

【 摘 要 】

Management of anticoagulation in elderly patients represents a particularly challenging issue. Indeed, this patient population is at high thromboembolic risk, but also at high hemorrhagic risk. Assessment of the benefit-risk balance of anticoagulation is the key point when decisions are made about introducing and/or continuing such treatments in the individual elderly patient. In order to maximise the safety of anticoagulation in the elderly, some specific considerations need to be taken into account, including renal insufficiency, modified pharmacodynamics of anticoagulants, especially vitamin K antagonists, and the presence of multiple comorbidities and concomitant medications. New anticoagulants could greatly simplify and possibly increase the safety of anticoagulation in the elderly in the near future.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland.