Inherently Chiral Calixarenes: Synthesis, Optical Resolution, Chiral Recognition and Asymmetric Catalysis

International Journal of Molecular Sciences

Shao-Yong Li¹  Yao-Wei Xu²  Jun-Min Liu² 

[1] College of Pharmacy, Tianjin Medical University, Tianjin 300070, China; E-Mail:;School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China; E-Mails:

关键词: inherently chiral calixarene;    synthesis;    optical resolution;    chiral recognition;    asymmetric catalysis;   

DOI  :  10.3390/ijms12010429

来源: mdpi

【 摘 要 】

Inherently chiral calixarenes, whose chirality is based on the absence of a planar symmetry or an inversion center in the molecules as a whole through the asymmetric array of several achiral groups upon the three-dimensional calix-skeletons, are challenging and attractive chiral molecules, because of their potential in supramolecular chemistry. The synthesis and optical resolution of all varieties of inherently chiral calixarenes are systematically discussed and classified, and their applications in chiral recognition and asymmetric catalysis are thoroughly illustrated in this review.

【 授权许可】

CC BY   
© 2011 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.