Schistosomicidal Activity of the Essential Oil of Ageratum conyzoides L. (Asteraceae) against Adult Schistosoma mansoni Worms

Molecules

Nathalya I. De Melo¹  Lizandra G. Magalhaes¹  Carlos E. De Carvalho¹  Kamila A. L. Wakabayashi¹  Gabriela De P. Aguiar¹  Rafael C. Ramos¹  Andre L. L. Mantovani¹  Izabel C. C. Turatti¹  Vanderlei Rodrigues¹  Milton Groppo¹  Wilson R. Cunha¹  Rodrigo C. S. Veneziani¹ 

[1] ¹Núcleo de Pesquisas em Ciências Exatas e Tecnológicas, Universidade de Franca, CEP 14404-600, Franca, SP, Brazil

关键词: Schistosoma;    essential oil;    Ageratum conyzoides;   

DOI  :  10.3390/molecules16010762

来源: mdpi

【 摘 要 】

The in vitro schistosomicidal effects of the essential oil of Ageratum conyzoides L. (Ac-EO) against adult worms of Schistosoma mansoni is reported in this paper. Concerning this activity, Ac-EO was considered to be active, but less effective than the positive control (praziquantel, PZQ) in terms of separation of coupled pairs, mortality, decrease in motor activity, and tegumental alterations. However, Ac-EO caused an interesting dose-dependent reduction in the number of eggs of S. mansoni. Precocene I (74.30%) and (E)-caryophyllene (14.23%) were identified as the two major constituents of Ac-EO. These compounds were tested individually and were found to be much less effective than Ac-EO and PZQ. A mixture of the two major compounds in a ratio similar to that found in the Ac-EO was also less effective than Ac-EO, thus revealing that there are no synergistic effects between these components. These results suggest that the essential oil of A. conyzoides is very promising for the development of new schistosomicidal agents.

【 授权许可】

CC BY   
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