Toward the Synthesis and Biological Screening of a Cyclotetrapeptide from Marine Bacteria

Marine Drugs

Rajiv Dahiya¹ 

关键词: natural product synthesis;    marine bacteria;    cyclic tetrapeptide;    biological activity;    Halisarca ectofibrosa;    Diginea sp;   

DOI  :  10.3390/md9010071

来源: mdpi

【 摘 要 】

The first synthesis of a naturally occurring tetrapeptide cyclo-(isoleucyl-prolyl-leucyl- alanyl) has been achieved using a solution-phase technique via coupling of dipeptide segments Boc-l-Pro-l-Leu-OH and l-Ala-l-Ile-OMe. Deprotection of the linear tetrapeptide unit and its subsequent cyclization gave a cyclopeptide, identical in all aspects to the naturally occurring compound. Bioactivity results indicated the antifungal and antihelmintic potential of the synthesized peptide against pathogenic dermatophytes and earthworms.

【 授权许可】

CC BY   
© 2011 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland