Protein Kinase C: An Attractive Target for Cancer Therapy

Cancers

Barbara Marengo¹  Chiara De Ciucis²  Roberta Ricciarelli²  Maria A. Pronzato²  Umberto M. Marinari² 

[1] G. Gaslini Institute, L.go G. Gaslini 5, 16147, Genoa, Italy; E-Mail:;Department of Experimental Medicine, General Pathology Section, University of Genoa, Via L.B. Alberti 2, 16132, Genoa, Italy; E-Mails:

关键词: apoptosis;    PKC;    cancer;    chemoresistance;   

DOI  :  10.3390/cancers3010531

来源: mdpi

【 摘 要 】

Apoptosis plays an important role during all stages of carcinogenesis and the development of chemoresistance in tumor cells may be due to their selective defects in the intracellular signaling proteins, central to apoptotic pathways. Consequently, many studies have focused on rendering the chemotherapy more effective in order to prevent chemoresistance and pre-clinical and clinical data has suggested that protein kinase C (PKC) may represent an attractive target for cancer therapy. Therefore, a complete understanding of how PKC regulates apoptosis and chemoresistance may lead to obtaining a PKC-based therapy that is able to reduce drug dosages and to prevent the development of chemoresistance.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.