SET/MYND Lysine Methyltransferases Regulate Gene Transcription and Protein Activity

Genes

Kristin Leinhart¹ 

[1] Colorado State University, Fort Collins, CO 80523, USA; E-Mail

关键词: SET;    MYND;    Smyd1;    Smyd2;    Smyd3;    transcriptional regulation;    chromatin modifications;    epigenetics;    tumorigenesis;   

DOI  :  10.3390/genes2010210

来源: mdpi

【 摘 要 】

The SET and MYND (SMYD) family of lysine methyltransferases is defined by a SET domain that is split into two segments by a MYND domain, followed by a cysteine-rich post-SET domain. While members of the SMYD family are important in the SET-mediated regulation of gene transcription, pathological consequences have also been associated with aberrant expression of SMYD proteins. The last decade has witnessed a rapid increase in the studies and corresponding understanding of these highly impactful enzymes. Herein, we review the current body of knowledge related to the SMYD family of lysine methyltransferases and their role in transcriptional regulation, epigenetics, and tumorigenesis.

【 授权许可】

CC BY   
©2011 by the authors; licensee MDPI, Basel, Switzerland.