The Ups and Downs of Tannins as Inhibitors of Poly(ADP-Ribose)glycohydrolase

Molecules

Christian Blenn¹  Philippe Wyrsch¹ 

[1]Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Winterthurerstrasse 260, 8057 Zurich, Switzerland[2] height:6px

[3]"> ^†These authors contributed equally to this work.

关键词: tannin;    gallotannin;    tannic acid;    PARG;    poly(ADP-ribose);   

DOI  :  10.3390/molecules16021854

来源: mdpi

【 摘 要 】

DNA damage to cells activates nuclear poly(ADP-ribose)polymerases (PARPs) and the poly(ADP-ribose) (PAR) synthesized is rapidly cleaved into ADP-ribose (ADPR) by PAR glycohydrolase (PARG) action. Naturally appearing tannin-like molecules have been implicated in specific inhibition of the PARG enzyme. This review deals with the in vitro and in vivo effects of tannins on PAR metabolism and their downstream actions in DNA damage signaling.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.