Mastic Oil Inhibits the Metastatic Phenotype of Mouse Lung Adenocarcinoma Cells

Cancers

Heleni Loutrari²  Sophia Magkouta²  Andreas Papapetropoulos¹ 

[1] Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504 Patras, Greece; E-Mail:;“G.P. Livanos and M. Simou Laboratories”, Evangelismos Hospital, Department of Critical Care and Pulmonary Services, School of Medicine, University of Athens, 3 Ploutarchou Street, 10675 Athens, Greece; E-Mails:

关键词: lung cancer;    prevention;    mastic plant essential oil;    invasion;    motility;    adhesion;    angiogenesis;   

DOI  :  10.3390/cancers3010789

来源: mdpi

【 摘 要 】

Mastic oil from Pistacia lentiscus variation chia, a natural combination of bioactive terpenes, has been shown to exert anti-tumor growth effects against a broad spectrum of cancers including mouse Lewis lung adenocarcinomas (LLC). However, no studies have addressed its anti-metastatic actions. In this study, we showed that treatment of LLC cells with mastic oil within a range of non-toxic concentrations (0.01–0.04% v/v): (a) abrogated their Matrigel invasion and migration capabilities in transwell assays; (b) reduced the levels of secreted MMP-2; (c) restricted phorbol ester-induced actin remodeling and (d) limited the length of neo-vessel networks in tumor microenvironment in the model of chick embryo chorioallantoic membrane. Moreover, exposure of LLC and endothelial cells to mastic oil impaired their adhesive interactions in a co-culture assay and reduced the expression of key adhesion molecules by endothelial cells upon their stimulation with tumor necrosis factor-alpha. Overall, this study provides novel evidence supporting a multipotent role for mastic oil in prevention of crucial processes related to cancer metastasis.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.