Genes | |
Enlightenment of Yeast Mitochondrial Homoplasmy: Diversified Roles of Gene Conversion | |
Feng Ling2  Tsutomu Mikawa1  | |
[1] Biometal Science Laboratory, RIKEN SPring-8 Center/Mikazuki cho, Hyogo 679-5148 Japan; E-Mail:;Chemical Genetics Laboratory, RIKEN Advanced Science Institute/2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan; E-Mail: | |
关键词: rolling circle replication; homologous pairing; D-loops; RecA/Rad51 family proteins; Rad52; Mhr1; Ntg1; endonuclease III homologues; concerted evolution; sequence homogenization; | |
DOI : 10.3390/genes2010169 | |
来源: mdpi | |
【 摘 要 】
Mitochondria have their own genomic DNA. Unlike the nuclear genome, each cell contains hundreds to thousands of copies of mitochondrial DNA (mtDNA). The copies of mtDNA tend to have heterogeneous sequences, due to the high frequency of mutagenesis, but are quickly homogenized within a cell (“homoplasmy”) during vegetative cell growth or through a few sexual generations. Heteroplasmy is strongly associated with mitochondrial diseases, diabetes and aging. Recent studies revealed that the yeast cell has the machinery to homogenize mtDNA, using a common DNA processing pathway with gene conversion;
【 授权许可】
CC BY
© 2011 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190050551ZK.pdf | 554KB | download |