Anti-Inflammatory and Antioxidant Components from Hygroryza aristata

Molecules

Yu-Ming Chung¹  Yu-Hsuan Lan¹  Tsong-Long Hwang¹ 

[1] ¹Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan ²School of Pharmacy, China Medical University, Taichung 40402, Taiwan ^†These authors contributed equally to this work.

关键词: Hygroryza aristata;    Gramineae;    hygarine;    anti-inflammatory;    antioxidant;   

DOI  :  10.3390/molecules16031917

来源: mdpi

【 摘 要 】

Twenty-six known compounds and two new compounds, including a new lignan, (7S*,8R*,7’R*,8’S*)-icariol A₂-9-O-b-xylopyranoside (1), and a new indole alkaloid, hygarine (2), were isolated from the extracts of Hygroryza aristata (Gramineae). The structures of all compounds were elucidated on the basis of NMR spectral analysis. The compounds (-)-epigallocatechin-3-O-gallate (4) and (-)-epicatechin-3-O-gallate (5) possess free radical scavenging activities and compound 1 could inhibit superoxide anion generation and elastase release by fMLP/CB-induced human neutrophils with IC50 values of 19.33 ± 0.86 and 24.14 ± 1.59 mM, respectively.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.