Predictive and Prognostic Factors in Colorectal Cancer: A Personalized Approach

Cancers

Myutan Kulendran¹  John F. Stebbing²  Christopher G. Marks² 

[1] id="af1-cancers-03-01622">Department of Coloproctology, Royal Surrey County Hospital NHS Foundation Trust, Egerton Road, Guildford,

关键词: predictive and prognostic factors;    colorectal cancer;    personalized medicine;    APC;    MSI;    MMR;    KRAS;    BRAF;    18qLOH;    CIMP;    TGF-β;    CIN;    MGMT;    TP53;    FOBT;    vimentin;    circulating tumor cells;   

DOI  :  10.3390/cancers3021622

来源: mdpi

【 摘 要 】

It is an exciting time for all those engaged in the treatment of colorectal cancer. The advent of new therapies presents the opportunity for a personalized approach to the patient. This approach considers the complex genetic mechanisms involved in tumorigenesis in addition to classical clinicopathological staging. The potential predictive and prognostic biomarkers which have stemmed from the study of the genetic basis of colorectal cancer and therapeutics are discussed with a focus on mismatch repair status, KRAS, BRAF, 18qLOH, CIMP and TGF-β.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.